Inhibition of microRNA-16 facilitates the paclitaxel resistance by targeting IKBKB via NF-kB signaling pathway in hepatocellular carcinoma
发布时间 :2018-10-22
研究对象:microRNA-16; 期刊:Biochemical and Biophysical Research Communications; 影响因子:2.62; 合作单位:中山大学附属第一医院器官移植中心; 发表日期:2018年8月


Hepatocellular carcinoma (HCC) is a common malignant tumor usually resistant to chemotherapy.MicroRNAs play important roles in modulation of carcinogenesis and chemoresistance, which miR-16 hasbeen reported to mediate chemoresistance in many types of cancers. However, the role of miR-16 in HCC remains unknown. The aim of this study was to investigate whether miR-16 is participated in chemo resistance in HCC and shed light on the underlying molecular mechanisms. The fifindings of the current study discover that miR-16 is down-regulated in HCC tissue and cell lines. The results demonstrate that the inhibition of miR-16 renders resistance to paclitaxel in vitro and in vivo by targeting IKBKB via NF-kB signaling pathway, suggesting that miR-16 may be a meaningful therapeutic potential to overcome drug resistance in HCC.

Keywords: miR-16, IKBKB, Paclitaxel , resistance, NF-kB, Hepatocellular, carcinoma